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Which Medication Program Monitors The Risk Of Severe Neutropenia
Neulasta can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Neulasta. These lists don’t include all possible side effects.For more information on the possible side effects of Neulasta, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be bothersome.Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. If you would like to report to the FDA a side effect you’ve had with Neulasta, you can do so through MedWatch.Mild side effectsThe mild side effects of Neulasta can include:bone pain (more information in “Side effect details” below)pain in your arms or legsMost of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist.Serious side effectsSerious side effects from Neulasta aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency.Serious side effects and their symptoms can include:Other serious side effects, explained in more detail below in “Side effect details,” include:Side effect detailsYou may wonder how often certain side effects occur with this drug. Here’s some detail on some of the side effects that may occur with either the Neulasta shot or patch.Allergic reactionAs with most drugs, some people can have an allergic reaction after taking Neulasta. It’s not known how many people had an allergic reaction to Neulasta in clinical trials. However, most reactions occurred in people who received a dose of Neulasta for the first time.And in some people, the reaction occurred again days later, after the treatment for the allergic reaction was stopped. An acrylic adhesive is used with the Neulasta on-body injector (OBI) and can cause an allergic reaction if someone has an allergy to adhesives.Symptoms of a mild allergic reaction can include:A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:swelling under your skin, typically in your eyelids, lips, hands, or feetswelling of your tongue, mouth, or throattrouble breathingCall your doctor right away if you have a severe allergic reaction to Neulasta. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency.Bone painBone pain is a common side effect of Neulasta. In clinical studies, 31% of people who took Neulasta reported bone pain compared with 26% of people who took a placebo (treatment with no active drug).It’s not known exactly why Neulasta causes bone pain in some people. One theory involves histamine, a protein that your immune system makes to help fight infections.Neulasta stimulates your immune system into producing more white blood cells, which also leads to more histamine being created. And the release of histamine has been linked to bone marrow swelling and pain. More research is needed before it’s known for sure why Neulasta causes bone pain.If you have bone pain while using Neulasta, tell your doctor. They may prescribe a medication for the pain, such as ibuprofen or naproxen. Or they may switch you to a medication other than Neulasta.Acute respiratory distress syndrome (ARDS)Acute respiratory distress syndrome (ARDS) is a possible side effect of Neulasta, but it rarely occurs. ARDS wasn’t reported during clinical trials of the drug, but the condition has been reported in a few people taking Neulasta since it came on the market.With ARDS, your lungs become filled with fluid and can’t deliver enough oxygen to the rest of your body. This could lead to other lung problems such as pneumonia or infections.Symptoms of ARDS can include:ARDS is a potentially life threatening condition that requires prompt medical care. If you’re taking Neulasta and you have trouble breathing, a fast rate of breathing, or shortness of breath, call 911 or go to the emergency room.Capillary leak syndromeCapillary leak syndrome is a rare but serious potential side effect of Neulasta. It’s not known for sure how often it occurred in clinical studies.Capillaries are tiny blood vessels. Capillary leak syndrome occurs when fluids and proteins manage to leak out of capillaries and into surrounding body tissue. This can cause low blood pressure and hypoalbuminemia (low levels of an important protein called albumin).Symptoms of capillary leak syndrome can include:As mentioned above, capillary leak syndrome is rare, but it can be fatal. So if you think you have symptoms of capillary leak syndrome while taking Neulasta, call 911 or go to the emergency room.GlomerulonephritisAlthough glomerulonephritis wasn’t reported in clinical studies of Neulasta, it’s been reported in people who took the drug since it came on the market.Glomerulonephritis refers to inflammation (swelling) of the glomeruli, which are clusters of blood vessels in your kidneys. Glomeruli help filter waste products from your blood and pass them into urine.Symptoms of glomerulonephritis can include:bloating and swelling due to fluid retention, especially in the face, feet, hands, or stomachhigh blood pressureurine that’s pink or dark brown in colorurine that looks foamyIf you think you have glomerulonephritis while taking Neulasta, tell your doctor. They may reduce your dose, which usually clears up glomerulonephritis. If that doesn’t work, your doctor will likely have you stop taking Neulasta. They may have you try a different medication instead.LeukocytosisLeukocytosis is a rare but potentially serious side effect of Neulasta.In clinical studies, leukocytosis occurred in less than 1% of people who took the drug. Neulasta was compared with a placebo, but it’s not known whether or how often leukocytosis occurred in people who took a placebo. No complications related to leukocytosis were reported in these studies.Leukocytosis is a condition in which the level of white blood cells called leukocytes is higher than normal. This is usually a sign that your body is trying to fight an infection. However, leukocytosis can also be a sign of leukemia (a cancer that affects the bone marrow or blood).Symptoms of leukocytosis can include:bleeding or bruisingbreathing problems such as wheezingfeverBecause you’re at an increased risk for infection while taking Neulasta, tell your doctor right away if you develop a fever or other symptoms of leukocytosis. They’ll help determine the cause and what treatment is right for you.Ruptured spleenAn enlarged spleen and a ruptured spleen weren’t reported in clinical trials of Neulasta. However, these conditions have been reported in people who took Neulasta since the drug came on the market.The spleen is an organ that’s in the upper left of your abdomen, under your ribs. It works to filter blood and fight infection.Symptoms of a ruptured spleen can include:confusionfeeling anxious or restlesslightheadednessnauseapain in the upper left area of the abdomenpale skinshoulder painA ruptured spleen is a life threatening condition requiring prompt medical care. If you’re taking Neulasta and have pain in your left shoulder or upper left abdomen area, tell your doctor right away.Fever (not a side effect)Fever isn’t an expected side effect of taking Neulasta.Keep in mind, Neulasta is used to help lower the risk of infection due to a condition called febrile neutropenia. This condition causes a fever along with a low level of white blood cells called neutrophils. Neulasta is also used to treat radiation sickness, which can cause fever. So, you may have a fever while taking this drug. But the fever could be due to the conditions being treated. Your fever may not be caused by Neulasta itself.Developing a fever during your Neulasta treatment may also mean you have an infection. Fever can also be a symptom of rare but serious side effects of Neulasta, such as acute respiratory distress syndrome (ARDS), aortitis, or leukocytosis. (For more about ARDS and leukocytosis, see those sections below.)If you develop a fever while taking Neulasta, tell your doctor right away. They can help determine what’s causing your fever and the best way to treat it.
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NORD – Severe Chronic Neutropenia
What is Severe Chronic Neutropenia? Severe chronic neutropenia, or SCN, is a rare blood disorder characterized by decreased neutrophils in the blood lasting from several months to a lifetime.
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