Which Antidepressant Medication Is A Selective Monoamine Oxidase-B Inhibitor MAOIs: Types, uses, side effects, and more

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Which Antidepressant Medication Is A Selective Monoamine Oxidase-B Inhibitor

Monoamine oxidase inhibitors (MAOIs) are a type of antidepressant that doctors sometimes prescribe for depression, panic disorders, and social anxiety.This article explores how MAOIs work and which dietary habits are important for people taking this type of drug.Below, we also describe other precautions, which types of MAOI are available, and what side effects to look out for.MAOIs are a type of antidepressant medication. As research from 2021 explains, doctors first started prescribing MAOIs in the 1950s, making them the oldest kind of antidepressant. Nowadays, doctors tend to only prescribe this type of drug when other medications have not been effective. This is because taking MAOIs requires important dietary restrictions and because these drugs can cause significant side effects. MAOIs affect the balance of certain chemicals in the brain. These chemicals are called neurotransmitters, and they are essential for brain function.MAOIs block an enzyme called monoamine oxidase, which breaks down the neurotransmitters in the brain. Taking this type of drug increases the levels of these neurotransmitters.A 2020 review notes that while scientists are unsure about the exact causes of depression, it seems likely that disturbances in levels of serotonin play an important role.Serotonin is one neurotransmitter among many, and scientists also believe that depression could involve disturbances in the levels of other neurotransmitters. These include:norepinephrinedopamineglutamatebrain-derived neurotrophic factorMonoamine oxidases are enzymes that breaks down certain neurotransmitters.There are two main types of monoamine oxidases: MAO-A and MAO-B. Both types break down the following neurotransmitters:norepinephrinedopaminetyraminetryptamineepinephrineMAO-A is most involved in breaking down serotonin. As MAOIs block this enzyme, the levels of serotonin, norepinephrine, and dopamine increase. When this occurs in the brain of someone with depression, their symptoms may improve, as a result. There are several types of drugs in this class.Some that have received approval from the Food and Drug Administration (FDA) include:selegilineisocarboxzaidphenelzinetranylcypromineSome of these medications come in pill form, while others come as adhesive patches that a person places on their skin. For example, selegiline is sold as a skin patch under the brand name Emsam.Tyramine is a type of chemical compound called a monoamine. Other types are neurotransmitters such as dopamine, serotonin, and norepinephrine. As research from 2020 describes, tyramine is a “trace” monoamine, which means that there are only small quantities in animal tissues. Taking MAOIs can increase tyramine levels in the body. If someone taking an MAOI eats foods with high quantities of tyramine, levels of this chemical in the body can rise dangerously high.High levels of tyramine can cause:headacheshigh blood pressurebrain bleeds, if the person’s blood pressure is very highWhich foods should a person avoid?The body produces little tyramine, but eating and drinking foods and beverages rich in tyramine will raise its level in the body. High-tyramine foods and drinks include:cheese, such as cheddar and fetafermented vegetables, such as kimchi and sauerkrautcured or salt-dried meatspickled or salt-dried shrimp or fishbeer and winesoy sauceWorcestershire saucechocolatecoffeesome fresh produce, like avocado, grapes, and beetsAlso, tyramine occurs in higher concentrations in older foodstuffs. For this reason, anyone taking MAOIs should avoid any pickled, fermented, and overripe food.MAOIs can interact with other drugs.It is important that anyone taking an MAOI does not also take a selective serotonin reuptake inhibitor (SSRI). Combining the two can lead to serotonin syndrome, which involves serotonin levels rising too high. Among the medications that can cause serotonin syndrome, MAOIs cause the more severe and prolonged cases.Serotonin syndrome can be fatal. For this reason, anyone taking an MAOI who experiences any of the following symptoms should contact a healthcare professional right away. Symptoms of serotonin syndrome include:agitation and restlessnessanxietydisorientationnausea and vomitingsweatinga rapid heart beata high body temperaturetremors and muscle jerksmuscle rigidityoveractive reflexesdilated pupilsflushed skinincreased bowel soundsIt is also dangerous to take more of an MAOI than was prescribed or to mix this type of drug with another antidepressant.In addition, doctors warn that anyone who has taken an MAOI the past 10 days should not undergo general anesthesia. This is to prevent any unwanted interactions between the antidepressant and the anesthetic.MAOIs can cause side effects, and common ones include:dry mouthnauseadiarrheaconstipationdrowsinessinsomniadizzinesslightheadednessAdditionally, MAOI skin patches can sometimes cause skin reactions.One 2018 study describes how antidepressant drugs can increase the likelihood of suicidal thoughts, behavior, and related death.SSRIs were the most likely to correlate with these effects. The authors of the study report that, in comparison, tricyclic antidepressants (TCAs) and noradrenergic and specific serotonergic antidepressants (NaSSAs) were very rarely correlated with these factors.And MAOIs were even less likely than TCAs and NaSSAs to correlate with suicidal thoughts, behavior, and related death.Doctors sometimes prescribe MAOIs to help treat depression, panic disorders, and social anxiety. The drugs block monoamine oxidase, which is an enzyme that breaks down neurotransmitters in the brain.However, because MAOIs have many side effects, and because new treatments are available, medical experts tend to prescribe MAOIs as a last resort.A person taking MAOIs needs to have a limited diet to help prevent levels of tyramine in their body from rising. Also, it is important to never combine an MAOI and an SSRI, as doing so can lead to serotonin syndrome, which can be fatal.

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Atypical antidepressants : monoamine oxidase inhibitors (MAOIs) , CNS Pharmacology , Dr Rajesh Gubba

📌𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:-
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The atypical antidepressants are distinct from other classes of antidepressants that include selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), serotonin modulators, tricyclics, and monoamine oxidase inhibitors (MAOIs). Atypical antidepressants are frequently used in patients with major depression who have inadequate responses or intolerable side effects during first-line treatment with selective serotonin reuptake inhibitors (SSRIs) . However, atypical antidepressants are often first-line treatment if the drug has a desirable characteristic (eg, sexual side effects and weight gain occur less often with bupropion than SSRIs).

#antidepressants #atypicalantidepressants #monoamine oxidase inhibitors #MAOIs #cnspharmacology #antidepressantpharmacology

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