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What'S The Difference Between Sustained Release And Extended Release

The “ER” in bupropion hydrochloride ER oral tablets stands for extended release, meaning that the drug is released slowly in the body. ER oral tablets include two forms of the drug. One form is sustained release (SR), which is generally taken twice daily. The other form is extended release (XL), and it’s taken once daily.The SR and XL forms of bupropion hydrochloride ER oral tablets both contain the active drug bupropion hydrochloride. So they can cause similar side effects that may be mild or serious. The following lists contain some of the key side effects that may occur while taking either of these medications. However, the lists don’t include all possible side effects.For more information about the possible side effects of these medications, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be concerning or bothersome.Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with the SR or XL form of bupropion hydrochloride ER oral tablets, you can do so through MedWatch.Mild side effectsMild side effects* can include:Most of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist.* This is a partial list of mild side effects from the SR and XL forms of bupropion hydrochloride ER oral tablets. To learn about other mild side effects, talk with your doctor or pharmacist, or view each medication’s prescribing information, which can be found here and here.† For information on this side effect, see “Side effect details” below.Serious side effectsAlthough rare, serious side effects from the SR or XL form of bupropion hydrochloride ER oral tablets can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.Serious side effects and their symptoms can include:* For more information about this side effect, see “Side effect details” below.† The SR and XL forms of bupropion hydrochloride ER oral tablets have a boxed warning for suicidal thoughts and actions. A boxed warning is the most serious warning from the FDA. For more information, see “Suicidal thoughts and actions” in “Side effect details” below.Side effect detailsHere are some details on certain side effects these medications may cause.Suicidal thoughts and actionsThe use of bupropion hydrochloride extended-release (ER) tablets may increase the risk for suicidal thoughts and actions in certain people. In fact, the SR and XL forms of bupropion hydrochloride ER oral tablets have a boxed warning regarding this. A boxed warning is the most serious warning from the FDA. The warning alerts doctors and patients about drug effects that may be dangerous.The increased risk is for children, teenagers, and young adults treated with antidepressants for various mental health conditions. (Bupropion hydrochloride is a type of antidepressant drug.) This warning is based on the results of short-term clinical studies of the SR and XL forms of the drug. No matter your age, your doctor will monitor you for symptoms of suicidal thoughts and actions during your treatment with either medication. Tell your doctor right away if you:think of harming yourselfhave new or worse depression symptomshave feelings of aggression or hostilityhave strange thoughts or actionsYour loved ones should also watch for and report any severe or strange changes in your mood or behavior to your doctor.If you have any concerns about suicidal thoughts and actions while using bupropion hydrochloride ER oral tablets, talk with your doctor.Weight lossWeight loss may occur with the use of either form of bupropion hydrochloride ER oral tablets (SR or XL). But weight loss isn’t considered a common side effect of these medications.Keep in mind that decreased appetite is a common side effect of the SR form of bupropion hydrochloride ER oral tablets. And eating less may lead to weight loss.Losing weight may also be a symptom of depression. If weight loss is a symptom of your depression, talk with your doctor before using the SR or XL form of bupropion ER oral tablets.You should also talk with your doctor if you’re currently using either drug and don’t feel hungry or lose too much weight. They may have you stop using the drug gradually and switch to a different antidepressant.Seizures Seizures may occur with use of either form of bupropion hydrochloride ER oral tablets (SR or XL).It’s unclear how often seizures occur with these medications. But the risk is greater if you take higher doses. You’re even more likely to have seizures if you take bupropion hydrochloride ER oral tablets and have any of the following risk factors:Tell your doctor if you have any of the seizure risk factors above before starting bupropion hydrochloride ER oral tablets.To help prevent seizures with the SR or XL form of bupropion hydrochloride ER oral tablets, your doctor will start you on a low dosage. They’ll gradually increase it as needed.Seizure symptomsWhile taking either of these medications, be sure to report any seizure symptoms to your doctor. Symptoms can include:confusionuncontrolled body movements or jerkingloss of consciousnessodd feelings or emotionsstrange smells or tastesIf you have a seizure while using the SR or XL form of bupropion hydrochloride ER oral tablets, your doctor will have you stop taking the drug. They’ll also work to treat your seizure symptoms and depression.Allergic reactionAs with most drugs, some people can have an allergic reaction after taking either form of bupropion hydrochloride ER oral tablets (SR or XL). It’s unknown how often allergic reactions occurred in people using these medications.Symptoms of a mild allergic reaction can include:skin rashitchinessflushing (temporary warmth, redness, or deepening of skin color)A more severe allergic reaction, including anaphylaxis, is rare but possible. Some people have reported these reactions while taking the medications. However, the reactions didn’t occur during clinical studies. So it’s unclear whether the reactions were caused by the medications, or how often the reactions occurred.Symptoms of a severe allergic reaction can include:swelling under your skin, typically in your eyelids, lips, hands, or feetswelling of your tongue, mouth, or throattrouble breathingextreme skin redness, blistering, or peelingCall your doctor right away if you have an allergic reaction with these medications, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

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