You are searching about Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels, today we will share with you article about Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels was compiled and edited by our team from many sources on the internet. Hope this article on the topic Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels is useful to you.
Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels
Thrombocytopenia is an autoimmune bleeding disorder in which the number of platelets in the blood is significantly lower than usual.The bone marrow produces platelets, which are blood cells that help stop bleeding by promoting blood clotting. When a person has fewer platelets than necessary, their blood may not clot fast enough, and they may experience bruising, spontaneous bleeding, and internal bleeding. In this article, we look at how thrombocytopenia can range in severity. We also discuss what makes platelets change shape and the symptoms, diagnosis, and treatment of thrombocytopenia. Doctors consider a healthy platelet count to fall within the range of 150,000–400,000 per microliter (μl) of blood. A lower number of platelets reduces their concentration.A person’s platelet count can fluctuate during menstruation and become low during the later stages of pregnancy.People are more at risk of bleeding the lower their platelet count drops. However, bleeding problems are unlikely until the platelet count is less than 100,000 platelets per μl.In a 2018 study, researchers categorized thrombocytopenia by platelet count as follows:Mild: 101,000–140,000 platelets per μl. The increase in the risk of bleeding when injured is minimal.Moderate: 51,000–100,000 per μl. The risk of bleeding and bruising when injured is slightly higher.Severe: 21,000–50,000 per μl. Minor bleeding may occur even without injury.Very severe: 20,000 per μl or below. This can result in spontaneous bleeding and can be life threatening.A doctor will likely begin the diagnosis of thrombocytopenia by asking questions about a person’s symptoms, medications, and family history. They may then perform a physical examination to assess bruising and rashes.The doctor will also draw blood to check the exact concentration of platelets. In some cases, they may request other tests, including:a complete blood count (CBC)a blood smear test to look at platelets under a microscopea bone marrow testother tests to check blood clottingsometimes, a bone marrow biopsy, which involves using a needle to take a sample of fluid from the marrowThere is no test for thrombocytopenia specifically. Therefore, a doctor will make the diagnosis by ruling out other causes of low platelets.In their nonactive form, platelets are plate-shaped. When a blood vessel becomes damaged, it sends a signal to the platelets, which respond by traveling to the damaged area. Here, they transform into their active shape, growing tentacles so that they can adhere to the broken blood vessel to plug the bleeding.This shape change results in the platelets spreading and creating a mesh formation to limit bleeding and close any gaps.The symptoms of thrombocytopenia may include:spontaneous and easy bruisingregular nosebleeds that are long lasting and difficult to stopbleeding in the gumsprolonged and heavy menstrual bleedinghemorrhaged blood vessels or leaks, which produce a rash that appears as small discolored dotsextreme fatiguedepressionblood blisters inside the cheeksrarely, signs of internal bleeding, such as blood in the stool or urinerarely, bleeding on the brain, called intracranial hemorrhageThe treatment options for thrombocytopenia will depend on its severity and the person’s medical history. Treatments may include:MedicationDoctors may treat thrombocytopenia using:CorticosteroidsCorticosteroids are the most effective first-line treatment for the disorder. They work by preventing the clearance of platelets by the immune system and possibly also by increasing the production of platelets. Examples include dexamethasone (DexPak), methylprednisolone (Medrol), and prednisone (Rayos).Thrombopoietin receptor agonists (TPO-RAs)These drugs work by stimulating the production of platelets. They include eltrombopag (Promacta), avatrombopag (Doptelet), and romiplostim (Nplate).Platelet transfusionIf treatment with medication is unsuccessful, a doctor may suggest intravenous immunoglobulins (IVIG) to replace platelets. Doctors typically only use this treatment in emergencies, as they do not consider it a cure. The reason for this is that the immune system will likely destroy the new platelets in time.SurgeryDoctors may suggest a splenectomy, which is a surgical procedure to remove the spleen. This treatment is usually only appropriate for severe cases of thrombocytopenia.Thrombocytopenia ranges from mild, involving a platelet count of 101,000–140,000 per μl of blood, to very severe, where a person has a platelet count of 20,000 per μl or lower. Severe cases of the disorder can be life threatening.A doctor will diagnose thrombocytopenia by asking questions, carrying out a physical examination, and running a series of medical tests. These may include blood tests, bone marrow tests, and tests to assess blood clotting.A doctor may treat symptoms of thrombocytopenia, such as regular nosebleeds, bruising, and bleeding in the gums, using corticosteroids, platelet infusion, or surgery.
Video about Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels
Hematology | Hemostasis: Coagulation Cascade
Official Ninja Nerd Website: https://ninjanerd.org
Ninja Nerds!
During this lecture Professor Zach Murphy will be teaching you about Hemostasis. We will be discussing the coagulation cascade including the intrinsic and extrinsic clotting mechanisms.
This video will cover the following topics:
1. Vascular Spasm
2. Platelet Plug Formation
3. Coagulation
4. Clot Retraction and Repair
5. Fibrinolysis
References:
● Le T, Bhushan V, Sochat M, Chavda Y, Zureick A. First Aid for the USMLE Step 1 2018. New York, NY: McGraw-Hill Medical; 2017
● Marieb EN, Hoehn K. Anatomy & Physiology. Hoboken, NJ: Pearson; 2020.
● Boron WF, Boulpaep EL. Medical Physiology.; 2017.
● Urry LA, Cain ML, Wasserman SA, Minorsky PV, Orr RB, Campbell NA. Campbell Biology. New York, NY: Pearson; 2020.
● Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison’s Principles of Internal Medicine. New York etc.: McGraw-Hill Education; 2018.
● Sabatine MS. Pocket Medicine: the Massachusetts General Hospital Handbook of Internal Medicine. Philadelphia: Wolters Kluwer; 2020
Join this channel to get access to perks:
https://www.youtube.com/channel/UC6QYFutt9cluQ3uSM963_KQ/join
APPAREL |
https://www.amazon.com/s?k=ninja+nerd&ref=nb_sb_noss_2
DONATE
PATREON | https://www.patreon.com/NinjaNerdScience
PAYPAL | https://www.paypal.com/paypalme/ninjanerdscience
SOCIAL MEDIA
FACEBOOK | https://www.facebook.com/NinjaNerdlectures
INSTAGRAM | https://www.instagram.com/ninjanerdlectures
TWITTER | https://twitter.com/ninjanerdsci
@NinjaNerdSci
DISCORD | https://discord.gg/3srTG4dngW
#ninjanerd #Hemostasis #Hematology
Question about Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels
If you have any questions about Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels, please let us know, all your questions or suggestions will help us improve in the following articles!
The article Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels was compiled by me and my team from many sources. If you find the article Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels helpful to you, please support the team Like or Share!
Rate Articles Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels
Rate: 4-5 stars
Ratings: 2330
Views: 23146830
Search keywords Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels
Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels
way Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels
tutorial Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels
Platelet Deficiency Resulting In Spontaneous Bleeding From Small Blood Vessels free
