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Administration Of Vaccination To Prevent Genital Warts Is Most Effective

The Food and Drug Administration (FDA) approves vaccines such as Gardasil 9 to prevent certain conditions.Gardasil 9 for preventing cervical, vulvar, vaginal, anal, and head and neck cancers caused by HPVGardasil 9 is FDA-approved to prevent several types of cancers that can be caused by the human papillomavirus (HPV). HPV is spread by vaginal, anal, or oral sex with someone who has the virus. Even if a person doesn’t show any symptoms, they may still be infected with HPV.According to the Centers for Disease Control and Prevention (CDC), HPV is the most common sexually transmitted infection.There are more than 100 types of HPV that can cause problems such as genital warts or cancer. Gardasil 9 protects against nine types. The vaccine contains proteins that are similar to each of these nine types of HPV.The types of HPV that cause cancer are different from the types of HPV that cause genital warts. Gardasil 9 protects against HPV-related anal cancer and head and neck cancers in males and females.* It also protects against the following types of HPV-related cancer in females:cervical cancervulvar cancervaginal cancerThese cancers can be caused by HPV types 16, 18, 31, 33, 45, 52, and 58. After getting the vaccine, you’d be protected from all of these types.* Sex and gender exist on spectrums. Use of the terms “male” and “female” in this article refers to sex assigned at birth.EffectivenessThe effectiveness of Gardasil 9 vaccine was tested in females* ages 16 through 26 years old. In this study, 6,016 females received Gardasil 9 and 6,017 females received Gardasil. (Gardasil is a now-discontinued vaccine that protected against four strains of HPV.) In the Gardasil 9 group, the vaccine was 96.7% effective at preventing abnormal changes or cancer in the cervix, vulva, or vagina.This study looked at HPV types 31, 33, 45, 52, and 58. These are the HPV types not prevented by the Gardasil vaccine. Only one female who received Gardasil 9 had an abnormal change or cancer in the cervix, vulva, or vagina. In comparison, 30 females who received the Gardasil vaccine (which doesn’t protect against these types of HPV) had abnormal changes or cancer in the cervix, vulva, or vagina.For two HPV types (16 and 18), clinical studies of Gardasil were used to show the effectiveness of Gardasil 9. The Gardasil vaccine and Gardasil 9 vaccine each protect against these types of HPV. In the Gardasil clinical studies, more than 24,000 people received Gardasil, and a similar number received a placebo (an injection with no vaccine). Gardasil was found to be effective in preventing HPV-related abnormal changes or cancer in the cervix, vulva, or vagina.Based on results of the studies described above, Gardasil 9 is also considered effective in the following age groups:males* ages 9 through 45 yearsfemales ages 9 through 15 yearsfemales ages 27 through 45 years* Sex and gender exist on spectrums. Use of the terms “male” and “female” in this article refers to sex assigned at birth.Gardasil 9 for preventing genital warts caused by HPVGardasil 9 is approved to prevent genital warts caused by HPV. (HPV is not the only cause of genital warts.)EffectivenessFor this purpose, clinical studies of the now-discontinued Gardasil vaccine were used to show the effectiveness of Gardasil 9. These studies showed the vaccine provided protection against HPV types 6 and 11.In clinical trials, Gardasil was 99% effective at preventing genital warts caused by HPV in females ages 16 through 26 years old. In males ages 16 through 26 years old, the vaccine was about 89% effective in preventing genital warts caused by HPV.In females ages 27 through 45 years old, Gardasil was between 87.7% and 95.0% effective in preventing genital warts caused by HPV.In males and females ages 9 through 15 years, studies looked at genital wart infections that occurred after vaccination and lasted for at least 1 year. No cases were observed in this age group after vaccination with Gardasil.In males ages 27 through 45 years, studies looked at whether Gardasil triggered a response from the immune system that was strong enough to protect against genital warts. Gardasil 9 was found to stimulate a strong immune response in this age group.Gardasil 9 for preventing precancerous or abnormal lesions caused by HPVGardasil 9 is FDA-approved to prevent precancerous growths or abnormal lesions caused by HPV.HPV can cause abnormal changes in your cervix, vulva, vagina, or anus. Some of these changes are called neoplasia, and they can lead to cancer in some people.By getting the Gardasil 9 vaccine, you can protect yourself against some of the HPV types that may cause these changes.EffectivenessClinical trials showed the effectiveness of the Gardasil 9 vaccine at preventing certain abnormal growths or changes caused by HPV.In one study, Gardasil 9 was more than 96% effective at preventing cervical intraepithelial neoplasia (abnormal cell growth in the lining of your cervix) or adenocarcinoma (cancer in your gland cells) caused by HPV types 31, 33, 45, 52 or 58. These are the HPV types whose effects are not prevented by the now-discontinued Gardasil vaccine.In the study, 5,948 females received the Gardasil 9 vaccine. In this group, there was one case of cervical intraepithelial neoplasia or adenocarcinoma. In comparison, in 5,943 females who received the original Gardasil vaccine, there were 27 cases of cervical intraepithelial neoplasia or adenocarcinoma.Other studies looked at Gardasil to show the effectiveness of Gardasil 9. This was done because the Gardasil vaccine and Gardasil 9 vaccine both protect against the four types of HPV covered in the studies: 6, 11, 16, and 18.In these clinical studies, more than 24,000 people received Gardasil, and a similar number received a placebo (an injection with no vaccine). Gardasil was found to be effective in preventing HPV-related precancerous or abnormal lesions caused by those four types of HPV.Because of these results, Gardasil 9 is considered effective for preventing them as well.Gardasil 9 and childrenGardasil 9 is approved for use in children ages 9 years and older. The CDC recommends the Gardasil 9 vaccine for children ages 11 or 12 years old. However, the CDC states that some people may benefit from getting the vaccine as early as age 9.Vaccinating children at a young age helps make sure they’re protected against the types of HPV that Gardasil prevents before they become sexually active.According to the CDC, HPV is the most common sexually transmitted infection. By immunizing your child, they’ll be protected from HPV-related changes in the cervix, vagina, vulva, anus, and head and neck tissues. They’ll also be protected from genital warts caused by the types of HPV prevented by the vaccine.Talk with your child’s doctor about their risk for HPV. Together, you can decide when it’s right to give the vaccine to your child.

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World Cancer Report Webinar Series – HPV Vaccination

Thirteen sexually transmitted human papillomavirus (HPV) subtypes are responsible for all cervical cancer globally (570 000 cases) and a proportion of other anogenital and oropharyngeal cancers (120 000 cases). Following the establishment of safety and high efficacy of HPV vaccines in clinical trials, data are rapidly accruing on the impressive effectiveness of real-life HPV vaccine programs, including strong herd immunity effects, and cervical cancer reduction. HPV vaccination programs are the cornerstone to the WHO Global Strategy on Cervical Cancer Elimination. Hence, in this webinar we will first learn about the impact of HPV vaccination in one of the earliest, and most successful introducing countries, namely Australia. This will be followed by an up to date picture of global progress in HPV vaccine implementation, with a focus on challenges in low- and middle-income countries.

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