Adjunctive Therapy To Treat Bipolar Disorder Commonly Focuses On Latuda: Side effects, generic, for depression, and more

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Adjunctive Therapy To Treat Bipolar Disorder Commonly Focuses On

Latuda can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Latuda. These lists don’t include all possible side effects.For more information on the possible side effects of Latuda, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be bothersome. You can also see this article for more information about Latuda’s side effects.Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to report to the FDA a side effect you’ve had with Latuda, you can do so through MedWatch.The specific side effects that you experience might differ slightly depending on whether you’re taking Latuda for bipolar I disorder or schizophrenia.Mild side effectsMild side effects of Latuda can include:*decreased ability to think clearly, make decisions, or coordinate the movement of your musclesakathisia (feeling restless or feeling the urge to move around)muscle stiffness or tremorstuffy or runny nosetrouble moving or slow movementsinsomnia (trouble sleeping)vomitingweight gain†sleepiness†nausea†Most of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist. * This is a partial list of mild side effects from Latuda. To learn about other mild side effects, talk with your doctor or pharmacist, or visit Latuda’s medication guide.† For more information, see “Side effect details” below. Serious side effectsSerious side effects from Latuda aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.Serious side effects and their symptoms can include: * Sex and gender exist on spectrums. Use of the terms “male” and “female” in this article refers to sex assigned at birth.† For more information, see “Side effect details” below.‡ Latuda has boxed warnings for these side effects. A boxed warning is the most serious warning from the FDA. For more information, see “FDA warnings” at the beginning of this article. Side effects in childrenLatuda is approved to treat schizophrenia in children ages 13 and older. The drug is also approved to treat bipolar depression in children ages 10 years and older.The side effects of Latuda in children are similar to the side effects in adults. See the “Mild side effects” and “Serious side effects” sections above for more information.Latuda has a boxed warning for the risk of suicidal thoughts and behaviors in children. A boxed warning is the most serious warning from the FDA. For more information, see “FDA warnings” at the beginning of this article.How long do side effects last?Most side effects of Latuda may go away within a few weeks after starting treatment. However, some side effects, such as tardive dyskinesia, may continue with long-term use. Talk with your doctor about your risk of experiencing long-term side effects with Latuda.Side effect detailsYou may wonder how often certain side effects occur with this drug. Here’s some detail on certain side effects this drug may cause.Allergic reactionAs with most drugs, some people can have an allergic reaction after taking Latuda. But it’s not known how often allergic reactions occurred in people who took the medication.Symptoms of a mild allergic reaction can include:skin rashitchinessflushing (warmth and redness in your skin)A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:swelling under your skin, typically in your eyelids, lips, hands, or feetswelling of your tongue, mouth, or throattrouble breathingCall your doctor right away if you have a severe allergic reaction to Latuda. Call 911 or your local emergency number if your symptoms feel life threatening, or if you think you’re having a medical emergency.Weight gainLatuda use may cause weight gain. In clinical studies, weight gain varied depending on the condition being treated.Weight gain in adultsIn studies of adults, they took either Latuda, olanzapine, extended-release quetiapine, or a placebo (treatment with no active drug).Among adults who took Latuda:A total of 3% gained weight.They gained an average of 0.2 to 0.9 pounds (0.1 to 0.4 kilograms).Between 2.4% and 4.8% had an increase of at least 7% in their body weight.Adults who took olanzapine gained an average of 9.2 lb (4.2 kg).Adults who took extended-release quetiapine gained an average of 4.6 lb (2.1 kg).Among adults who took a placebo:Less than 1% gained weight.Some people lost between 0.04 and 0.09 lb (0.02 and 0.04 kg).Some people gained an average of 0.4 lb (0.2 kg).Between 0.7% and 3.3% of people had an increase of at least 7% in their body weight.Weight gain in childrenIn studies of children, they took either Latuda or a placebo.Researchers found the following in children who took Latuda:A total of 7% gained weight.They gained an average of 1.1 to 1.5 lb (0.5 to 0.7 kg).Between 3.3% and 4% had an increase of at least 7% in their body weight.Researchers found the following in children who took a placebo:A total of 2% gained weight.They gained an average of 0.4 to 1.1 lb (0.2 to 0.5 kg).Between 4.5% and 5.3% had an increase of at least 7% in their body weight.If you’re concerned about weight gain while taking Latuda, talk with your doctor. They may want to check your weight at each appointment.SleepinessA common side effect of Latuda is sleepiness (drowsiness). The percentage of people who experienced sleepiness in clinical studies varied depending on the condition being treated.In adults, sleepiness occurred in:7% to 26% of adults treated with Latuda5% to 7.1% of adults treated with a placeboIn children, sleepiness occurred in:11% to 15% of children treated with Latuda6% to 7.1% of children treated with a placeboFeeling sleepy after you take Latuda may go away within a few weeks. If you’re concerned about sleepiness while taking the medication, talk with your doctor. They may suggest ways to help ease this side effect.NauseaNausea is a common side effect of Latuda. The percentage of people who had nausea in clinical studies varied depending on the condition being treated.In adults, nausea occurred in:7% to 17% of adults treated with Latuda5% to 10% of adults treated with a placeboIn children, nausea occurred in:13% to 16% of children treated with Latudaonly 3% to 6% of children treated with a placeboIf you have nausea after taking Latuda, you can ask your doctor about ways to relieve this side effect.Tardive dyskinesiaTardive dyskinesia, which refers to uncontrolled muscle movements, is a possible side effect of Latuda. Your risk of developing tardive dyskinesia may increase as you keep taking the medication.In a clinical study of children with bipolar depression, the children took Latuda or a placebo for 6 weeks. Tardive dyskinesia occurred in:less than 6% of children treated with Latudaless than 5% of children treated with a placeboIt’s not known what percentage of children had tardive dyskinesia while taking Latuda for schizophrenia.It’s also not known what percentage of adults in these studies had tardive dyskinesia.Symptoms of tardive dyskinesiaSymptoms of tardive dyskinesia include involuntary, repetitive, and jerking movements of your tongue, neck, face, arms, or legs. Symptoms may occur even after you stop taking Latuda.Talk with your doctor if you develop symptoms of tardive dyskinesia while using Latuda. They may prescribe a different medication to treat your condition.Risk of death in older adults with psychosis related to dementiaIn some cases, antipsychotic drugs such as Latuda can increase the risk of death when used in older adults who have psychosis related to dementia.* Psychosis is a symptom of mental illness in which you lose touch with reality. And dementia refers to symptoms of problems with thinking, communication, and memory.In clinical studies, older adults with psychosis were 1.6 to 1.7 times more likely to die after using an antipsychotic than a placebo.If you’re an older adult and have dementia-related psychosis, you should not take Latuda. Talk with your doctor about other treatment options for your condition. * Latuda has a boxed warning for the risk of death in older adults with psychosis related to dementia. A boxed warning is the most serious warning from the FDA. For more information, see “FDA warnings” at the beginning of this article. Suicidal thoughts and behaviorsLatuda may increase the risk of suicidal thoughts and behaviors in children and young adults.*In clinical studies, the number of suicidal thoughts and behaviors in children and young adults was greater when they were given medications (such as Latuda) to treat their depression. For every 1,000 people given medications to treat their depression:14 more children younger than age 18 years reported suicidal thoughts or behaviors, compared with those who took a placebo5 more people ages 18 to 24 years reported suicidal thoughts or behaviors, compared with those who took a placeboIn clinical studies, no suicides were reported among children who took medications (such as Latuda) to treat their depression. And although there were suicides among adults who took the drugs in the studies, the number was too low for researchers to reach a conclusion as to how often the suicides occurred.Changes in moodIf you have any of the following changes in mood while using Latuda, tell your doctor right away:But if you have any suicidal thoughts or behaviors while taking Latuda, call 911 or your local emergency number right away. * Latuda has a boxed warning for the risk of suicidal thoughts and behaviors. A boxed warning is the most serious warning from the FDA. For more information, see “FDA warnings” at the beginning of this article.

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Adjunctive BRIGHT LIGHT THERAPY in the Management of Bipolar Depression

University of Washington, Department of Psychiatry & Behavioral Sciences, Grand Rounds. Dorothy Sit, MD. « Adjunctive BRIGHT LIGHT THERAPY in the Management of Bipolar Depression » presented on January 7, 2022. For more information, visit our department website at https://psychiatry.uw.edu/​

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