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Abatacept Is Prescribed For A Patient With Severe Rheumatoid Arthritis
Orencia can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Orencia. These lists do not include all possible side effects.For more information on the possible side effects of Orencia, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be bothersome.More common side effectsThe more common side effects of Orencia can include:upper respiratory infections, such as the common cold or a sinus infectionheadachenauseaMost of these side effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk with your doctor or pharmacist.Serious side effectsSerious side effects from Orencia aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency.Serious side effects, which are discussed below in “Side effect details,” can include the following:Side effect detailsYou may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. Here’s some detail on several of the side effects this drug may or may not cause.Serious infectionsYou may have a higher risk of serious infections while you’re taking Orencia. This is because the drug makes your immune system less able to protect you from infections.In clinical studies, 54% of people taking Orencia had infections. Infections were considered serious in 3% of people taking Orencia in the studies. Of those who took a placebo (treatment with no active drug), 48% had infections. Infections were considered serious in 1.9% of people who took the placebo. The most common serious infections affected people’s lungs, skin, urinary tract, colon, and kidneys.Symptoms of an infection can vary, depending on which part of your body is affected. They may include:feverfeeling very tiredcoughflu-like symptomswarm, red, or painful areas on your skinLet your doctor know if you have symptoms of an infection. They may recommend certain tests to see what kind of infection you have. If needed, they’ll also prescribe medications to treat your infection.In some cases, it may be hard to treat serious infections while you’re taking Orencia. If you have an infection, your doctor may recommend that you stop taking Orencia until your infection is gone.Also, your doctor will want to make sure that you don’t have either a hepatitis B or tuberculosis (TB) infection before you start taking Orencia. The hepatitis B virus affects your liver, and TB affects your lungs. These viruses may or may not cause symptoms. When they don’t, you may not know you have the infection. Knowing if you have hepatitis B or TB will help your doctors determine whether Orencia is safe for you to use. See “Orencia precautions” below for details.Epstein-Barr virus or cytomegalovirusIn people receiving Orencia to help prevent acute (sudden) graft-versus-host disease, the drug may cause infection with cytomegalovirus or Epstein-Barr virus. These are serious viral infections.Also, if you’ve had either infection in the past, Orencia can cause the virus to become active again and start causing symptoms.To prevent graft-versus-host disease, Orencia is typically given with other medications to help prevent the two infections. Your doctor will monitor you for signs of these and other infections during and after your Orencia treatment.Allergic reactionAs with most drugs, some people can have an allergic reaction after taking Orencia. In clinical studies, less than 1% of people taking Orencia had an allergic reaction. Symptoms of a mild allergic reaction can include:A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:swelling under your skin, typically in your eyelids, lips, hands, or feetswelling of your tongue, mouth, or throattrouble breathingCall your doctor right away if you have a severe allergic reaction to Orencia. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency.CancerYou may have an increased risk of cancer if you take Orencia. This drug can affect the way your cells function and may increase how quickly your cells grow and multiply (make more cells). These effects can cause cancer.In clinical studies, 1.3% of people taking Orencia developed cancer. Of those not taking Orencia, but who took a placebo (treatment with no active drug), 1.1% had the same result. In most cases, the cancer occurred in people’s lungs and blood.It’s not known if the cancer was caused by using Orencia. It’s possible that other factors played a role in its development.Symptoms of cancer can vary depending on the area of your body that’s affected. Symptoms may include:neurological changes (such as headaches, seizures, vision or hearing problems, or being paralyzed in your face)bleeding or bruising more easily than usualcoughfatigue (lack of energy)feverswellinglumpsweight gain or weight lossTell your doctor if you have any symptoms of cancer. They’ll recommend certain tests to see if you’ve developed cancer. If you have cancer, they’ll recommend treatment for it. They’ll also discuss with you whether it’s still safe for you to take Orencia.Skin rashIn clinical studies, skin rash wasn’t a serious side effect in people taking Orencia. Of people with RA who took Orencia, 4% had a rash during studies. Of those who took placebo (treatment with no active drug), 3% had a rash. A mild skin rash can also occur in the area of your body where Orencia is injected.In some cases, a skin rash can be a symptom of an allergic reaction. (See the “Allergic reaction” section above.)If you have a skin rash that doesn’t go away while you’re using Orencia, tell your doctor. They’ll talk with you about what may be causing your skin rash. They may ask if you have symptoms of a serious allergic reaction. If you’re having an allergic reaction, your doctor will prescribe medications to reduce your allergy symptoms, and they may have you stop using Orencia.Weight gain (not a side effect)During clinical studies, weight gain wasn’t a side effect in people taking Orencia.If you’re concerned about weight gain while you’re using Orencia, talk with your doctor.Hair loss (not a side effect)In clinical studies, hair loss wasn’t a side effect in people taking Orencia. But hair loss may occur in people with certain forms of arthritis, including those that Orencia may be used to treat.Let your doctor know if you’re concerned about hair loss, or if you have hair loss while you’re using Orencia. They may recommend tests to try to figure out why it’s happening and offer ways to help you cope with the side effect.Fatigue (not a side effect)Fatigue (lack of energy) wasn’t a side effect in people taking Orencia during clinical studies. But some people with different forms of arthritis (such as those that Orencia is used to treat) may experience fatigue.Tell your doctor if you have fatigue that doesn’t go away while you’re using Orencia. They’ll recommend certain tests to help figure out the cause of your fatigue. If needed, they may also prescribe medications to help relieve your fatigue.
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